Search results for "Sustained release"

showing 8 items of 8 documents

Halloysite nanotubes for efficient loading, stabilization and controlled release of insulin

2018

Hypothesis: Oral insulin administration is not actually effective due to insulin rapid degradation, inactivation and digestion by proteolytic enzymes which results in low bioavailability. Moreover insulin is poorly permeable and lack of lipophilicity. These limits can be overcome by the loading of protein in some nanostructured carrier such as halloysite nanotubes (HNTs). Experiments: Herein we propose an easy strategy to obtain HNT hybrid materials for the delivery of insulin. We report a detailed description on the thermal behavior and stability of insulin loaded and released from the HNTs hybrid by the combination of several techniques. Findings: Release experiments of insulin from the H…

Dichroismmedicine.medical_treatmentHalloysite nanotube02 engineering and technology01 natural sciencesBiochemistryNanocompositesChitosanchemistry.chemical_compoundColloid and Surface ChemistryDrug StabilityProtein stabilityHalloysite nanotube (HNTs)InsulinTransdermalSettore CHIM/02 - Chimica FisicaDrug CarriersNanotubesProteolytic enzymes021001 nanoscience & nanotechnologyControlled releaseSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsEnzyme inhibitionAluminum SilicatesBionanocomposite film0210 nano-technologyHybrid materialBionanocomposite hybridSurface PropertiesDrug Compoundingengineering.materialCircular dichroism data010402 general chemistrySustained release InsulinAdministration CutaneousHalloysiteBiomaterialsKaolinitemedicineParticle SizeHybrid materialChitosanInsulinBiomedical applicationMedical applicationYarn Bio-nanocompositeMembranes Artificial0104 chemical sciencesNanotubeDrug LiberationHalloysite nanotubes Insulin Protein stability Sustained release Bionanocomposite hybridchemistryChemical engineeringDelayed-Action PreparationsengineeringClayNanocarriersSustained release
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In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

2019

Graphical abstract

In situPO Propylene oxideIV IntravenousP338 Poloxamer 338lcsh:RS1-441Pharmaceutical Sciencechemistry.chemical_compoundn Sample sizeSD Standard deviationIM Intramuscularchemistry.chemical_classificationC0 Analyte plasma concentration at time zeroDoE Design of experimentsUV UltravioletPharmacology. TherapyK2.EDTA Potassium ethylenediaminetetraacetic acidLC–MS/MS Liquid chromatography-tandem mass spectrometryH&E Hematoxylin and eosintmax Sampling time to reach the maximum observed analyte plasma concentrationIn situ forming gelsCMC Critical micellar concentrationCmax Maximum observed analyte plasma concentrationIntramuscular injectionDN Dose normalizedGPT Gel point temperaturePLGA Poly-(DL-lactic-co-glycolic acid)TFA Trifluoroacetic acidCAN AcetonitrileATP Adenosine 5′ triphosphateSalt (chemistry)Polyethylene glycolPoloxamerArticlelcsh:Pharmacy and materia medicaPharmacokineticsIn vivoUHPLC Ultra-high performance liquid chromatographyPharmacokineticsAUClast Area under the analyte concentration versus time curve from time zero to the time of the last measurable (non-below quantification level) concentrationEO Ethylene oxideNMP N-methyl-2-pyrrolidoneComputingMethodologies_COMPUTERGRAPHICSAUC∞ Area under the analyte concentration vs time curve from time zero to infinite timeP407 Poloxamer 407In vitro releasePoloxamerCMT Critical micellar temperatureGel erosionIn vitrot1/2 Apparent terminal elimination half-lifechemistryMDR-TB Multi-drug resistant tuberculosisAUC80h Area under the analyte concentration versus time curve from time zero to 80 htlast Sampling time until the last measurable (non-below quantification level) analyte plasma concentrationMRM Multiple reaction monitoringNuclear chemistrySustained releaseInternational Journal of Pharmaceutics: X
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Nanohydrogel Formation within the Halloysite Lumen for Triggered and Sustained Release

2018

An easy strategy to obtain nanohydrogels within the halloysite nanotube (HNTs) lumen was investigated. Inorganic reverse micelles based on HNTs and hexadecyltrimethylammonium bromides were dispersed in chloroform, and the hydrophilic cavity was used as a nanoreactor to confine the gel formation based on alginate cross-linked by calcium ions. Spectroscopy and electron microscopy experiments proved the confinement of the polymer into the HNT lumen and the formation of calcium-mediated networks. Biological tests proved the biocompatibility of the hybrid hydrogel. The nanogel in HNTs was suitable for drug loading and sustained release with the opportunity of triggered burst release by chemical …

NanotubeMaterials scienceBiocompatibilityChlorine compound02 engineering and technologyNanoreactorHexadecyl trimethyl ammonium bromideengineering.materialHybrid hydrogel010402 general chemistry01 natural sciencesMicelleHalloysiteSustained release Drug deliveryAdsorptionKaoliniteHalloysite nanotube (HNTs)Chemical stimuliGeneral Materials ScienceControlled drug deliveryBiological testSettore CHIM/02 - Chimica Fisicachemistry.chemical_classificationTargeted drug deliveryCrosslinkingReverse micellePolymer021001 nanoscience & nanotechnology0104 chemical sciencesChemical engineeringchemistryYarn Biological applicationengineeringBiocompatibilityCalcium0210 nano-technologyMicelleNanogelACS Applied Materials & Interfaces
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Novel Drug Delivery System for Treatment-Resistant Schizophrenia

2021

Settore CHIM/09 - Farmaceutico Tecnologico Applicativotreatment-resistant schizophrenia clozapine oral transmucosal delivery solid dosage form unidirectional delivery sustained release profile
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Polymeric drug delivery micelle-like nanocarriers for pulmonary administration of beclomethasone dipropionate

2017

In this paper, the potential of novel polymeric micelles as drug delivery systems for Beclomethasone Dipropionate (BDP) administration into the lung is investigated. These nanostructures are obtained starting from α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA), which was subsequently functionalized with O-(2-aminoethyl)-O’-methylpolyethylenglycole (PEG2000), ethylenediamine (EDA) and lipoic acid (LA), obtaining PHEA-PEG2000-EDA-LA graft copolymer. Empty and drug-loaded micelles possess adequate chemical-physical characteristics for pulmonary administration such as spherical shape, slightly positive surface charge and mean size of about 200 nm. Besides, BDP-loaded micelles, obtained …

Surface PropertieAnti-Inflammatory AgentsBiocompatible MaterialsMucin permeation02 engineering and technologyPharmacology030226 pharmacology & pharmacyMicelleAntioxidantsDrug Delivery Systems0302 clinical medicineNanoparticleColloid and Surface ChemistryCopolymerDrug CarrierLungMicellesmedia_commonCell uptakeBiocompatible MaterialDrug CarriersLipoic acidThioctic AcidChemistryBeclomethasoneSurfaces and InterfacesGeneral Medicinerespiratory systemEthylenediamines021001 nanoscience & nanotechnologyPolyaspartamideAnti-Inflammatory AgentDrug deliveryPeptideAntioxidant0210 nano-technologyDrug carrierSurfaces and InterfaceHumanBiotechnologyDrugBiocompatibilitySurface PropertiesCell Survivalmedia_common.quotation_subjectEthylenediamineBronchi03 medical and health sciencesMicroscopy Electron TransmissionPolymeric micelleHumansSurface chargeParticle SizePhysical and Theoretical ChemistryEpithelial CellEthanolEpithelial CellsMicroscopy FluorescenceSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoNanoparticlesNanocarriersPeptidesDrug Delivery SystemNuclear chemistrySustained releaseMicelle
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Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties

2021

AbstractIn this work, we investigated the effects of the vacuum pumping on both the loading efficiencies and the release kinetics of halloysite nanotubes filled with drug molecules dissolved in ethanol. As model drugs, salicylic acid and sodium diclofenac were selected. For comparison, the loading of the drug molecules was conducted on platy kaolinite to explore the key role of the hollow tubular morphology on the filling mechanism of halloysite. The effects of the pressure conditions used in the loading protocol were interpreted and discussed on the basis of the thermodynamic results provided by Knudsen thermogravimetry, which demonstrated the ethanol confinement inside the halloysite cavi…

Sustained release Clay nanoparticles Drug loading Halloysite nanotubes Knudsen thermogravimetryMaterials scienceKineticsNanochemistryDiclofenac Sodiumengineering.materialHalloysiteThermogravimetryChemical engineeringengineeringKaoliniteMoleculeFourier transform infrared spectroscopySettore CHIM/02 - Chimica FisicaJournal of Nanostructure in Chemistry
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Chemical gels of scleroglucan obtained by cross-linking with 1,w-dicarboxylic acids: Synthesis and characterization

2005

Chemical gels obtained by cross-linking reaction between scleroglucan and I, omega-dicarboxylic acids having a number of carbon atoms from 4 to 8 in the chain, have been prepared and characterised. The networks show properties correlated with the number of carbon atoms of the acid and with the molar ratio carboxylic acid/glucose unit of the polymer (r) employed in the cross-linking reaction. The diffusion of theophylline, chosen as model drug, through the swelled cross-linked polymers has been also investigated and it has enabled the diffusion coefficients of the drug to be calculated under different environmental conditions. The release profiles of theophylline from tablets prepared with t…

chemistry.chemical_classificationDiffusionCarboxylic acidPharmaceutical Sciencechemistry.chemical_element1-omega-dicarboxylic acidPolymerSustained release dosage formsControlled releasechemistrycross-linking reactionPolymer chemistrySelf-healing hydrogelsmedicineTheophyllinehydrogelcontrolled releaseCarbonscleroglucanmedicine.drug
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In Vitro Evaluation of Poly(lactide-co-glycolide) In Situ Forming Gels for Bedaquiline Fumarate Salt and Pharmacokinetics Following Subcutaneous Inje…

2021

This study evaluated in vitro and in vivo drug release of bedaquiline from in situ forming gels (ISGs) containing 200 mg eq./g bedaquiline fumarate salt prepared with four different grades of poly(d,l-lactide) (PDLLA) or poly(d,l-lactide-co-glycolide) (PLGA) with a lactide/glycolide ratio of 50/50 or 75/25 and acid (A) or ester (E) end-capping in N-methyl-2-pyrrolidone at a polymer/solvent ratio of 20/80% (w/w). Mean in vitro drug release in 0.05 M phosphate buffer pH 7.4 with 1% (w/v) sodium lauryl sulphate was 37.3, 47.1, 53.3, and 62.3% within 28 days for ISGs containing PLGA5050A, PDLLA, PLGA7525A, and PLGA7525E, respectively. The data suggested that drug release was primarily controlle…

porosityBedaquilinein vitro releasePharmaceutical SciencedissolutionPolyethylene glycolArticleDiffusionchemistry.chemical_compoundSubcutaneous injectionPharmacy and materia medicaPharmacokineticsIn vivoPharmacokineticsin situ forming gelsSolubilitybedaquilinesustained releaseinjectableLactidepolymer erosionPharmacology. TherapydiffusionIn vitro releasePolymer erosionRS1-441PLGAInjectablechemistryIn situ forming gelsBedaquilinePorositypharmacokineticsDissolutionNuclear chemistrySustained releasePharmaceutics
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